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Lecture

Chapter 4a-1.docx

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Department
Biology
Course Code
BIOL 2000
Professor
Joseph Rasmussen

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Chapter 4a-1 Mapping Eukaryote Chromosomes by Recombination Defintitions:  Recombinant product- a product of meiosis that differs from the haploid genotypes that give rise to the diploid meiocyte  Parental product- a product of meiosis that is the same as the haploid genotypes that gave rise to the diploid meiocyte  Dihybrid- an individual heterozygous at two genes  Coupling configuration- arrangement of linked alleles in dihybrid such that the two dominant alleles are on one chromosome, the two recessive alleles are on the other chromosome (AB/ab)  Repulsion configuration- arrangement of linked alleles in a dihybrid such that the a dominant and a recessive allele are together on each chromosome (Ab/aB)  Cis dihybrid- a dihybrid in which the alleles are coupled  Trans dihybrid- a dihybrid in which the alleles are in repulsion  Map unit- the distane between two genes where one product of meiosis out of 100 is recombinant  Gene locus- the position of a gene within the genome  Linked- two genes that are on the same chromosome  Linkage group- a set of genes that are on the same chromosome  Unlinked- two genes that assort independently *( a/a ; B/b) either on different chromosomes or >50cM apart on the same chromosome  CentiMorgan- cM is equal to 1% recombinant progeny  Trihybrid- an individual heterozygous at three genes  Interference- a measurement of the degree to which a cross-over in one interval inhibits a cross-over in a second interval  Linear tetrad- a tetrad resulting from meiosis in which sister products are adjacent to one another  First division segregation (MI) – a linear array of tetrads (4:4) produced from a heterozygous meiocyte, when the alleles separate after Meiosis I; indicative of no crossovers between the gene and centromere  Second division segregation (MII)- a linear array of tetrads (2:2:2:2) produced from heterozygous meiocyte when the alleles separate
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