NEUR 1000 Lecture Notes - Lecture 11: Sirolimus, Antisense Therapy, Neuroenhancement
4 Apr 2016
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Neuroscience 3850: final exam study guide (part ii) Chapter 5: consolidating synaptic changes (translation and transcription) S-ltp is a product of the post-translation processes. L-ltp depends on production of new proteins and related biochemical pathways. Transcription is the process of converting genetic material from. Translation is the process of messenger rna into protein. Standard view of protein synthesis: translation and mrna are distributed within the dendrite and soma; mrna is translated as it passes through a membrane system that surrounds the nucleus. Local protein synthesis: messenger rna and protein translation machinery (endoplasmic reticulum and ribosomes) is present locally in the dendritic spine region. Evidence for role of local protein synthesis in consolidation of synaptic changes: two research strategies: separating dendrites in the ca1 region from the cell bodies. Final exam: thursday december 10 2015: diferential input of apical basilar dendrites of ca1 cell. Two ways to signal the nucleus: synapse to nucleus, some to nucleus is camp-responsive.
