AN SC100 Lecture Notes - Lecture 3: Immunoglobulin G, Immunoglobulin D, Immunoglobulin M
23 Jun 2018
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IMMUNITY PART 2 (QUIZ ON FRIDAY)
Inflammation – an innate mechanice
Exposure to trauma, heat, chemicals, microbial invasion…
Results in tissue damage, releasing alarmins and /or….
Toll-like receports recgonize pathogen-associated molecular partters (PAMPs)
oLipopolysaccharide or Lipoteichoic Acids
TLRS or Alarmins trigger innate immune defenses of Sentinel Cells which results in inflammation
5 Classical Signs of inflammation:
oRedness (rubor)
oHeat (calor)
oPain (dolar)
oSwelling (tumor)
oLoss of function (function laesa)
Inflammation does NOT = infection
Use “-itis” to indicate inflammation
ACUTE VS. CHRONIC (terminology) these terms refer to duration NOT severity
Acute: (suddenly)
Sudden onset
Short duration
Does NOT imply severity
May be mild OR severe
Chronic: (been around for a while)
Onset slow
Long lasting
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Document Summary
Results in tissue damage, releasing alarmins and /or . Toll-like receports recgonize pathogen-associated molecular partters (pamps: lipopolysaccharide or lipoteichoic acids. Tlrs or alarmins trigger innate immune defenses of sentinel cells which results in inflammation. 5 classical signs of inflammation: redness (rubor, heat (calor, pain (dolar, swelling (tumor, loss of function (function laesa) Chronic (terminology) these terms refer to duration not severity. May being with acute episode that does not resolve, or recurs. Something causes inflmattion to happen (two things can happen: 1. Activation of sentintel cells: vasoactive molcules released. Makes capillaries / blood vessels bigger and leaky (acts locally at the site: cytokines (cell-signaling protein moleciles) Systemic responses (act more broadly in the body system) The immune-system: cell-mediated immunity (cells doing the work, humoral immunity (part that"s in the bloodstream; antibody related) *** diagmra of the essesital features of the acquired immune system (humoral immunity = green side)
