Class Notes (839,087)
Canada (511,185)
Biochemistry (187)
BIOCH200 (135)

BIOCH 200 (April 4, 2014) - Glucose Metabolism

3 Pages

Course Code
Walter Dixon

This preview shows page 1. Sign up to view the full 3 pages of the document.
BIOCH 200 Glucose Metabolism (April 4, 2014) • Why does pyruvate require anaerobic fate? o So it can be used to produce useful compounds even in the absence of oxygen. Pyruvate has no useful purpose as is.  Ex. lactate  (NOT an acid) via lactate dehydrogenase • *The “lactic acid” myth o *Lactic acid is not being produced, only lactate o *The acidic environment that led to this myth comes from the release of H+ ions into the muscle cells caused by the pyruvate to lactate conversion o *With rest, [lactate] goes down as well as [H+] because they are symported out thus taking the acidity with it. • Causes muscle cramping when muscles partake in anaerobic exercise o Leaves muscle tissue by being exported by a specific membrane transport protein • *A “dead-end” product that has no useful purpose… in muscle tissue that is! o *Lactate can be used as metabolic fuel for cardiac muscles. How?  1) Converted back into pyruvate • In doing so, reduced NAD+ back into NADH which can now travel to the ETC  2) Converted to Acetyl-CoA and CO2 • This reduces another NAD+ into NADH  Then it is oxidized by CAC (Citric Acid Cycle) • Glycolysis Produces: o 2 pyruvate o 2 NADH o Net yield of 2 ATP molecules • *Pyruvate  Acetyl CoA (aerobic pathway of pyruvate) o *Catalyzed by pyruvate dehydrogenase complex (PDH)  *What happens: • *Oxidative decarboxylation (which is actually just oxidation and decarboxylation) • *Transacetylation (transfer of acetyl to Coenzyme A)  Cofactors needed: • N
More Less
Unlock Document

Only page 1 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.