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Lecture

BIOCH 200 (February 10, 2014) - Protein Structure and Function

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Department
Biochemistry
Course
BIOCH200
Professor
Walter Dixon
Semester
Winter

Description
BIOCH 200 (February 10, 2014) • Proteins: o Composed of more than one polypeptide chain where each one is referred to as a subunit  2 = dimer; 3 = trimer; 4 = tetramer  *If the subunits are the same, it is called a homo___mer  *If the subunits are different, it is called a hetero___mer o Is the quaternary structure:  *Like tertiary structure, it is MAINLY stabilized by hydrophobic interactions. H-bonding and ion interactions help make strengthen it. The Structure and Function of Myoglobin and Hemoglobin • Myoglobin is a monomer • *Hemoglobin is a oligomer (more specifically, a tetramer) • *Remember that the function of a protein is determined 100% by its physical structure! o *3-D structure dependent on the primary structure • *Hemoglobin binds to oxygen in the lungs and carriers it to the tissues where it releases the oxygen for myoglobin to pick up. o Think of it like a baton pass: Lungs with oxygen pass it to hemoglobin which runs to the destination (tissue) and passes it on to myoglobin. • Red blood cells = erythrocytes • Myoglobin Function: o Facillitate oxygen diffusion through muscle tissue o *Acts as O 2torage for muscles  Allows for efficient diffusion of oxygen to muscles o Store O 2n aquatic animals as well. • *The function of proteins depends a lot on its ability to bind to other molecules called ligands IN A REVERSIBLE WAY! o *The greater the affinity, the higher the [protein-ligand complex] is compared to the [protein] and [ligand] individually o *If you kept adding ligands to a solution of proteins, it would eventually reach a saturation point  this is when the total allowable protein-ligand bonds have been created. o *If there are two ligands that a protein can bind to, the one that the protein has the highest affinity for will have a higher saturation rate and therefore will reach 100% saturation first. • The structure of myoglobin o *8 α
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