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Lecture

BIOCH 200 (February 24, 2014) - Protein Structure and Function

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Department
Biochemistry
Course
BIOCH200
Professor
Walter Dixon
Semester
Winter

Description
BIOCH 200 – Protein Struture and Function (con’t) | (February 24, 2014) • Hyperbolic curve as to myoglobin like Sigmoidal curve as to hemoglobin o Hyperbolic curve of myoglobin is representative of constant affinity  Ligand affinity (d ) does not change o Sigmoidal curve of hemoglobin is indicative of cooperative binding affinity  *Deoxyhemoglobin has a lower affinity for oxygen than an oxyhemoglobin that still has a subunit available for oxygen binding.  *The binding of each subsequent oxygen molecule to the hemoglobin protein increases the affinity of hemoglobin for oxygen. • *Via conformation changes • *Remember that: o Myoglobin is important between tissues (mainly muscle tissue) o Hemoglobin is important for oxygen transport from the lungs to tissues • The two distinct structures of Hemoglobin (Hb) o Tense (T-state)  *Larger, more open form  *BUT has a lower affinity for oxygen  *His residue in β subunit is wedged between Thr and Pro in the α subunit  Characteristic structure of deoxyhemoglobin o Relaxed (R-state)  *Is a more constricted structure  *BUT has a higher affinity for oxygen  *His
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