BIOCH200 Lecture Notes - Hydrogen Bond, Fluorine, Formal Charge

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Bioch 200 introductory lecture and biomolecules (con"t) | Nucleotides and nucleic acids (january 8, 2014) Water: overall, there is no formal charge on a water molecule, the electron density is greatest at the oxygen atom therefore it is slightly negative. Hydrogen bonding occurs between molecules and not within molecules. 2 hydrogen atoms to act as hydrogen bond acceptors. *generally, the longer the bond, the weaker it is. *also, they can only form between the hydrogen atom and either oxygen, nitrogen, or fluorine. Van der waals forces: there are 2 types, dipole-dipole interactions. Slightly positive atoms of a molecule are attracted to slightly negative atoms of another molecule: london dispersion forces. Is due to slight differences in electronegativity of atoms within a molecule that has no overall dipole. Occasionally a dipole forms on its own but only for a short instance and will sometimes flip in directionality. The interaction between molecules experiencing these instances are called london dispersion forces.

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