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Lecture

BIOCH 200 (January 20, 2014 ) - Nucleotides and Nucleic Acids

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Department
Biochemistry
Course
BIOCH200
Professor
Walter Dixon
Semester
Winter

Description
BIOCH 200 – Nucletides and Nucleic Acids con’t (January 20, 2014) • The primary structure of DNA is the sequence of nucleotide residues • *DNA forms a double-helix structure o *The most common form of DNA is the B-form of DNA  *Alternating major and minor groves of DNA and the helix is twisted in the right-hand direction • *10 base pairs per turn • DNAs helical structure deduce by Watson and Crick with help from Erwin Chargaff o *Ratio of A:T and C:G were always approximately 1 o A + G = T + C  Number of purines = Number of pyrimidines • Hydrogen Bonds o By polar interactions o Much weaker than covalent bonds  *In fact, hydrogen bonds aren’t actually bonds but rather a sharing/tug-of-war of electrons  *They may be weak but altogether, they make for a significant amount of stabilizing force • *However, h-bonds are NOT the mos
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