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BIOCH 200 (March 24, 2014) - Metabolism & Oxidative Phosphorylation

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Walter Dixon

BIOCH 200: Metabolism & Oxidative Phosphorylation (March 24, 2014) • Enzyme regulation o *Irreversible steps are usually regulated o *Reversible steps are not enzymatically regulated; but enzymes present to help the reaction along • *Rate-limitting step: is an irreversible step of the pathway that determines the overall rate • Metabolic Inhibition o *The production of a product leads to its own inhibition  By inhibiting the enzyme that converts the previous substrate into the said product.  *This is called product inhibition because it is the product that inhibits o *Feedback inhibition  *The presence of a product inhibits that PATHWAY that leads to its creation  this is to save energy (you don’t want to make a whole lot of intermediates and then not have anything to do with them…. This is a waste of energy therefore it would be better to shut down this pathway until the [product] goes back down) • Metabolic Activation o *Upstream metabolites may cause the activation of an enzyme downstream that produces another metabolite  To make sure that the pathway is going in order  *“Feed-Forward Activation” • Reciprocal Activation o *Some pathways may be reversed at the cost of ATP  *If there are irreversible steps in this pathway, how to you get reversal? Enzymes will either be bypassed OR will be temporarily replaced with another enzyme that facilitates the reverse reaction.  This is regulated to make sure that the pathways do not happen at the same time  redundancy • *Ex. if there are two irreversible steps, BOTH of them will be replaced by their respective reverse reaction enzymes o Ex. gluconeogenesis START of “Oxidative Phosphorylation” Lecture • *Two separate phenomena that occur in close proximity to each other (in the inner membrane of the mitrochondria) o Oxidation  Reduced electron carriers pass on electrons to the terminal electron carrier Oxygen to generate Water molecules
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