BIOCH200 Lecture Notes - Adipose Tissue, Oxidative Phosphorylation, Uncoupling Protein

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*the phosphate/oxygen ratio (p/o ratio) relates how much atp is synthesized from however much oxygen is needed: for nadh, it is 2. 5. *higher ratio means higher h+ transport out of the matrix from e- transport 2 e- travelling through etc cause 10 h+ to leave the matrix: for fadh2, it is 1. 5. 2 e- travelling through etc leads to the pumping out of 6 h+ from the matrix: *in both cases though, 4 h+ are needed for the synthesis of an atp molecule. *3 of which are involved with the atp synthase. *1 of which is involved with the phosphate symporter. *phosphate source for atp synthesis comes from the cytosol and needed to be imported into the mitochondrial in this way. This fat is metabolized for the sole purpose of providing heat when energy is not really needed (during hibernation, the animal only needed enough energy to stay warm) *the use of this coupling protein is not constitutive though.

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