BIOCH200 Lecture Notes - Globular Protein, Alcohol Dehydrogenase, Reaction Rate
10 Apr 2014
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*there are 2 ways of enhancing reaction rate: *adding heat. Not good for biological reactions since excess heat causes denaturation. Good for organic chemistry reactions though: *adding a catalyst. All enzymes are proteins: enzymes accelerate reaction rate and are recovered at the end, increase rxn rate by 106 to 1020x, nomenclature, *typically end in -ase . Ex. catalase: *typically contain substrate/product name and the chemical reaction. Ex. citrate synthase enzyme that synthesizes citrate. Ex. alcohol dehydrogenase enzyme that removes hydrogen from alcohol molecules. Ex. pyruvate decarboxylase enzyme that removes carboxyl groups from pyruvate: enzymes are regulated, some of this regulation comes from changes in shape which could change or inactivate a function. *how do enzymes work: *work by decreasing the activation energy needed for a reaction to proceed. *stabilizes the transition state by reducing its free energy. *activation energy is notated: g : weird symbol is called: double dagger .
