BIOCH410 Lecture Notes - Lecture 14: Thymidine Kinase, Thymidine, Negligee
12 Feb 2020
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Imaging: diagnostic tool (staging) but also can suggest what treatment strategy should taken. Introduce radio-labelled organism into a living organism. The imaging probes participate nina biological pathway that is related to a disease without disturbing the pathway. Thymidine and brdu get incorporated to cells in s phase. We can only target the proliferative cells. So you need to know the p:q ratio. It is only expressed in p cells and not go cells. Marked thymidine only gets into dna of s phase of proliferating ells. 18f-iso, sigma 2 receptors are exclusively expressed in cells that are in the cell cycle and not the go state. Ki67 - hosing only cells in cell cycle. Pcna: only showing s phase , high dna synthesis rate. Tk1: over expressed in highly proliferative cells line. Thymidine kinase drives thymidine to be incorporated in the dna. A: before treatment and then reduction of flt uptake.
