BIOCH410 Lecture Notes - Lecture 6: Tumor Suppressor Gene, Sarcoma, Oncovirus

• School: University of Alberta
• Department: Biochemistry
• Course: BIOCH410
• Professor: Carlos Patron

Document Summary

The rout sarcoma virus even though it is a chicken virus, the virus genome contained a gene for sarcoma (mammalian) Discovered you can have virus population that can have the native / normal gene and another population of virus which had the sarcoma protein (mutated) and was always active. By then it was known src was kinase and involve din regulation of growth signal. Meant that mutations result din activation of src (always active) That mutation caused src to be always active. If mutations make tumor suppressor genes active, it cannot stop forth and chances of cancer increases. Mutations can also happen inside the viruses. Genes more prone to mutation once inside the virus. The rsv has proteins on its envelop to recognize speci c terminals on host cells. Integrate themselves to the genome of the cell. Before that they have to ve inverted from retrovirus (rna to dna) The dna gets integrated to genome of the host.