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Lecture 10

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Biology (Biological Sciences)
Lesley Harrington

Lec10 BIOL207 2014-01-27 CHAPTER 5 A. Pedigree analysis a. used when cannot make controlled crosses, e.g. human genetics b. research applications: i. identify heritable traits; people in my family have 6 fingers… is this genetic or environmental? ii. determine mode of inheritance; we follow inheritance through a couple generations iii. identify linked genes; are these autosomal or sex-linked genes; c. clinical applications: i. diagnosis ii. genetic counselling iii. forensics d. notation: i. filled = affected (i.e. manifests trait of interest); black; remember the phenotype is only representative of the phenotype; ii. half-filled = (we rarely use this); carrier, a heterozygote who has a recessive bad trait, but it is difficult to do this. iii. unfilled = unaffected (includes carriers; carriers have an allele for the trait but don’t show the phenotype); iv. circle = female; square = male e. mode of inheritance i. AD (autosomal inheritance) every affected individual must have an affected parent ii. XD (X-linked dominant) cannot be XD if affected father has affected son (assuming mother is not affected); but all daughters of an affected father must be affected  fathers will not pass their X-chromosome to their son, so X-linked dominant on its own cannot show
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