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Lecture 10

BIOL107 Lecture Notes - Lecture 10: Mreb, Ftsz, Globular Protein

Biology (Biological Sciences)
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Biol107-Lecture 10-Prokaryotic Cytoskeleton & Cell Movement
Prokaryotic Cytoskeleton & Cell Movement
Cytoskeleton: internal network of fibers (fibers are protein in general)
which is implicated in cell shape, cell division, and movement (of cell
contents and of the actual cell).
Some cytoskeleton shapes are spherical, rod-shaped, and spiral and this
gives shape to the bacteria
Cytoskeletal fibers are made of chains of globular protein or bundles of
fibrillar protein
Amino acids covalently attach (bond) to each other and the long chain
becomes a fiber chain
Cytoskeleton has different kinds of protein providing different functions
Examples of Cytoskeleton in Bacteria
MreB: homologue of actin in Eukaryotes. Gives bacteria its rod-shape and it
is probably used as a guiding scaffold in the deposition of new cell wall
during growth.
RodZ: another protein that works in conjunction with MreB to shape the
prokaryotic cell.
Crescentin: a coiled-coil like bacteria, bending bacilli into a curved shape
(crescent shape)
FtsZ: form a band (ring) around the midpoint of the cell—the “Z ring.” This
constricts the cell form inside. It creates a strangulation in the cell during
division that leads to septation (divide), eventually resulting in 2 daughter
cells. It creates the partition out of the same wall, and this is why binary
fission is possible.
If the synthesis of FtsZ is prevented, then the bacteria will grow as large as
possible and then lyse because they can’t sustain the growth of the cell, so
they’ll die.
This is a new avenue for strains of pathogenic bacteria with multiple-
resistance to current situations. It’s good to target bacteria’s Z-ring.
ParM: moves DNA to opposite ends of the cell prior to division by growing
in between the DNA and pushing them
Cell Movement
Mobility: the cell can move, but not by itself (i.e. floating). Cell is mobile
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