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Lecture 36

BIOL107 Lecture Notes - Lecture 36: Cyclin B1, Microtubule, Myocyte


Department
Biology (Biological Sciences)
Course Code
BIOL107
Professor
Damián Cirelli
Lecture
36

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Biol 107 Lecture 36 Notes
Written by Ramesh Mahdavifar
Lecture 36: cell cycle regulation
Cells can "exit" the cycle and enter the G0 state
Permanently: neurons
Temporarily: liver cells
In many tissues contact inhibition is a major trigger to enter the G0 state (cells can sense their
neighbours)
Some cells reproduce continuously
These do not remain in G0
Examples:
Epithelial cells → replace themselves (first pic)
Need to replace these continuously
Required to divide at a constant rate
Bone marrow cells → produce blood cells (bottom pic)
Life of RBC is about 90 days, so we need to constantly replenish this and have
them recycled in spleen

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Some cells reproduce if required
Only reproduce when required to do so
Examples:
White blood cells (left pic)
Hepatocytes (liver cells) (right pic)

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Q: The liver can regenerate after it has lost a maximum of. . .:
A: A. 10%
B. 25%
C. 50%
D. 75%
E. 90%
Some cells cannot reproduce
Remain pretty much forever in G0
Examples:
Neurons (left pic)
If you have a traumatic brain injury, you can not regenerate that much of the
neuron
Red blood cells (right pic)
Can not reproduce because they do not have a nucleus
Plant cells reproduce at specific sites
One difference: some cells are in G0
They have groups of cells called meristems
They reproduce constantly; process is ongoing (except in winter obviously)
Lateral meristems also reproduce cells constantly, causing increase in girth of tree
Other cells can also reproduce if required
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