BIOL201 Lecture Notes - Lecture 11: Tradd, Tnf Receptor Superfamily, Caspase 8
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15 Apr 2012
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Biology 201 Dr. Torah Kachur
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Lecture 11 – Apoptosis
Introduction
We have been discussing how cells can divide and how that division can be controlled. However, the
pathways controlling where and when a cell dies are critical to maintaining the health of an organism.
Apoptosis, or Programmed Cell Death, is a major cellular pathway that is highly controlled by both intra-
and extracellular signals.
Objectives:
Define: Apoptosis, cytochrome c, cell survival factors, caspase, Bcl-2, apoptosome,
phagocytosis,
Outline three examples of when a cell would want to undergo apoptosis
Describe the cellular changes that occur once apoptosis is triggered
Outline two anti-apoptotic signals
Outline three pro-apoptotic signals or conditions
Explain the function of a caspase
How are caspases activated?
Outline the function of the mitochondria in apoptosis, what other function does the
mitochondria have?
Describe 2 main targets of Bcl-2
How is Bcl-2 activated?
Describe two possible ways that a cancer cell could avoid apoptosis
Lecture Outline
1. Purpose (Page 591-592)
Biology 201 Dr. Torah Kachur
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2. Characteristics (Page 592, Figure 19-44)