BIOL201 Lecture Notes - Lecture 19: Anaphase-Promoting Complex, Spindle Apparatus, Cleavage Furrow

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Cdk can get activated: cdk activating kinase* cdk has 3 sites: 2 inhibitory and 1 for activation. Kinesin related proteins push centrosomes apart, similar to polar mt during anaphase b. kinesins are walking to slide away from each other. Nuclear envelope fragments** caused by phosphorylation of lamin (forms nuclear lamina inside nuclear envelop. Mitotic spindle attaches to the centromere region of chromosomes. Lamin (inside the nucleus, makes up the nuclear lamina- phosphorylated by mitotic cdk to induce fragmentation of the nuclear envelope. 3 key activities: kinetochore-mt: active during anaphase a- responsible for pulling the chromosomes from the center of the cell to spindle poles- 2 molecular motors. One in the kinetochore and the other at the spindle pole- pulls chromosomes. These pushes the spindle poles away from each other: astral mt: walk along the mt from the + to ends on the mt of the spindle poles. All responsible for the separation of the chromosomes*

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