BIOL201 Lecture Notes - Lecture 8: Electrochemical Gradient, Glycogen, Cell Membrane
8 Mar 2016
School
Department
Course
Professor
Document Summary
Different members of the collagen family have a variety of additional protein motifs interpersed with the core collagen motif. Provide more flexibility, ability to organize 2 or 3 dimensions and form mechanically strong ecm structures. Proteoglycans: ecm molecules with a protein core and very large amounts of long-cain charged polysaccharides. The charged polysaccharides are very hydrophilic, water binds to them and does not easily release. Result: acts like a big blob of stiff jelly. Major component of cartilage: acts like a cushion, deforms while absorbing energy, can be bent, but resists, so flexible but returns to original shape. Water rich, therefore has low friction on the surface of cartilage. Has multiple domains that bind other different ecm components. Major binding partner for the integrins, cell surface receptors for. Can be found soluble in the blood as well. Fibronecting (one of the components for blood clots, supports the growth of cells into the clot as part as the healing process).
