BIOL207 Lecture Notes - Okazaki Fragments, Sister Chromatids, Condensin

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Chromosomes during the cell cycle (con"t) & human. Near the end of replication, an after the removal of the rna primers, the lagging strand is a bit shorter than the parent strand. Because dna polymerase only works from 3" to 5" direction and not the other way around . Telomerase is able to extend the parental (longer strand) so that okazaki fragments can attach the complimentary bases. Telomerase is an exception to the dna is replicated using an ssdna template" nucleic acid rule. The ends of chromosomes are covered by telomeres for protection. Dna + histone proteins = nucleosome: histone proteins aid in the condensation of genetic material. When the chromosomes of a cell are getting ready to condense (prophase), they actually separate within the nucleus into chromosome territories. Each chromosome has it"s own territory: this arrangement results in no overlapping and makes it easier for the chromosomes to condense. Cohesion holds sister chromatids together: composition: smc2 + smc3.

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