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BIOL207 Lecture Notes - Mitosis, Zygote, Meiosis

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bronzesalmon403
15 Sep 2013
School
University of Alberta
Department
Biology (Biological Sciences)
Course
BIOL207
Professor
Mike Harrington

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Document Summary

Lecture 3: human chromosomes (con"t) & lecture 4: genes and. Gene the part of dna responsible for the production of rna. Transcription factors bind with regulatory region: positive turns gene on", negative turns gene off". There are multiple possible names for the above set-up: (multiple nomenclatures to show relations): ***note: there is a different between homologous and homozygous!! Homologous refers to two chromosomes being the same (having the same genes) and homozygous refers to a gene having the 2 identical alleles! Naturally, that means that heterozygous is a gene with 2 different alleles. At stage g2, the chromosomes within a diploid cell have been duplicated. The x chromosome in fruit flies is also called chromosome 1. Purpose of mitosis: to produce 2 daughter cells identical to it. Purpose of meiosis: to produce 4 haploid cells with half the # of chromosomes and genes (either of two heterozygous alleles have a 50/50 chance of being passed on to a haploid cell)

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Related Questions

Messenger RNA (mRNA)...

a) Is a structural part of a ribosome

b) Brings amino acids to DNA

c) Carries genetic information from the nucleus to the cytoplasm

d) Is a structural part of a chromosome

e) Initiates and directs chemical reactions

Mr. Potato is homozygous dominant (KK), his son, Potato Jr. is heterozygous (Kk). Based on this information, what are the possible genotypes for Mrs. Potato? (Hint: use a Punnet Square).

a) Her genotype is definitely kk

b) Her genotype is either Kk or kk

c) Her genotype is either KK or Kk

d) Her genotype is either KK, or Kk, or kk

e) Mr. Potato cannot be Potato Jr’s biological father

12. Homologous chromosomes:

a) Are members of different chromosome pairs

b) Are genetically identical

c) Carry genetic information that influences the same traits (same genes but probably different alleles)

d) Are only inherited from the mother

e) Are only inherited from the father.

“Fitness” in an evolutionary sense, refers to an individual’s:

a) Strength

b) Reproductive success

c) Aggressiveness

d) Size

e) Age at death

The fact that individuals who possess favorable traits are more likely to survive and reproduce than those who possess less favorable traits is the basis for the theory of...

a) uniformitarianism.

b) natural selection.

c) the inheritance of acquired characteristics.

d) catastrophism.

e) the fixity of species.

Even with strong selection, genetic variation of a population can be maintained because:

a) Selection only affects one gene at a time.

b) The effects of many alleles are hidden from selection by the effects of other alleles

c) Mutation constantly adds new alleles at an extremely fast rate.

d) Populations always go extinct before their gene frequencies are dramatically altered.

e) Only a and c

Gene Flow is defined as the:
a) Production of new alleles
b) New musical group in which Adam Levine will be the leading vocalist
c) Exchange of genes between populations
d) differential reproductive success of individuals
e) Process by which a DNA base gets extracted out of the nucleus to initiate the process of protein synthesis.

The basic unit of DNA is a molecule called a: a) Nucleotide

b) Base
c) Thymine
d) Prokaryoticcell e) mRNA

How many bases code for one amino acid? a) one

b) two
c) it depends on what amino acid it is d) three
e) four

Hemophilia is a condition that affects: a) more females than males
b) more males than females
c) females and males equally

d) only children born prematurely
e) individuals with a missing portion of chromosome number 5

A clear example of directional selection is:
a) Darwin finches with deeper and thicker beaks associated to a severe drought b) Sickle cell anemia in regions in which Malaria is endemic
c) Achondroplasticdwarfism
d) Fly halteres becoming fully developed wings after modification of a hox gene e) all of the above

Meiosis is evolutionarily significant because:
a) New combination of alleles can arise through independent assortment and crossing over

22.

23.

24.

25.

26.

b) It is the mechanism by which body tissues are repaired
c) It creates somatic cells that are crucial for our body organs to maintain us alive d) It allows forensics to determine the cause of death of unidentified people
e) none of the above

Homologous chromosomes:

a) Are exact copies of each other and contain exactly the same genetic material
b) Are members of different chromosome pairs
c) Are only inherited from the father
d) carry genetic information that influences the same traits (the same genes), however, each of the homologous chromosomes can contain different versions of the same gene (different alleles).

e) carry genetic information that influences different traits because each of the homologous chromosomes contains completely different genes at very different loci

How many chromosome pairs occur in a normal human somatic cell?

a) 46 b) 23 c) 22 d) 24 e) 45

What is the scientific method? Use bullet points to describe the 4 major components.

How is a hypothesis different from a theory?

List the four major components (described during class) necessary for natural selection to occur [AKA Darwin’s Four Postulates] (PDF1-3).

27. Who was Thomas Malthus? In what way(s) Malthus was influential for Darwin’s Theory of Natural Selection? Hint: populations vs resources.

29. What amino acids are being coded for by the gene segment provided below? Nucleotide triplets and their corresponding amino acids are:
ACA= Cysteine; AAA=Phenylalanine; TGG=Threonine; CCT=Glycine; GAT=Leucine; ATA=Tyrosine; AGG=Serine; TCT=Arginine

a) Threonine, serine, glycine, tyrosine, leucine, phenylalanine, arginine, cysteine.

b) Tyrosine, leucine, glycine, threonine, arginine, threonine, serine, cysteine.

c) Arginine, cysteine, serine, glycine, threonine, leucine, phenylalanine, tyrosine.

d) Phenylalanine, leucine, tyrosine, glycine, serine, threonine, cysteine, arginine.

e) Phenylalanine, leucine, tyrosine, glycine, threonine, phenylalanine, arginine, serine.

Expression vectors inprokaryotes do not make functional eukaryotic gene products inbacteria very well because

Answer Not sure which one ?!

· the codon sequence for prokaryotes is differentthan the codon sequence in eukaryotes

· there are no disulfide bridges formed in proteinsnormally made in prokaryotes

· prokaryotic expression vectors cannot translateeukarytic sequences

· eukaryotic genes have introns, and prokaryotesdon't

· eukaryotic genes have exons and prokaryotesdon't


I create a knockout mouseusing the agouti/black fur system \. When I cross the agoutioffspring of the originally engineered mouse, I find a ratio of 2agouti mice to 1 black furred mouse. What is the bestexplanation?

Answer not sure which one?!

· The gene knocked out was recessive.

· The gene knocked out was dominant.

· The gene knocked out was a lethalgene.

· The knockput was integrated into a random spot,and did not knockput the original gene.

A restriction enzyme cuts DNAand leaves the following end

xxCTGCA
xxG

Which of the following could be the sequence of the correspondingend of the other end of the cut DNA?

Answer

· xxG
xxCTGCA

· xxC
xxGTGCA

· xxCCGAT
xxG

· xxGGCTA
xxC


An SNP always occurs dueto

Answer

· a one base-pair change.

· a three base-pair change.

· a single restriction site change.

· a single amino acid change.

· None of these.


I PCR out a mutated gene in apatient with Lisenbee chorea (the inability to dance in acoordinated fashion) and I compare it to another patient with thatsame disease phenotype. One subject had a mutation on chromosome 4,and the other subject couldn't rock it because of a mutation onchromosome 5. This is an exampe of

Answer

· pleitropy

· locus heterogeneity

· allelic heterogeneity

· dominant negative mutation

· penetrance

In his experiments, Mendelnoted that when two traits are involved in a genetic cross, theyare inherited independently of each other. Though Mendel didn'tknow about chromosomes, this still holds true (mostly)because

Answer

· genes on the same chromosome are often mixedthrough meiotic crossover during the formation ofgametes.

· variant alleles of the same gene do not interferewith the phenotypic expression of the gentoype in different geneticloci.

· most higher organisms are diploid, making only twoalleles available for every genetic locus, and there is a 50/50chance of geting either allele from a single parent.

· expression of phenotypes can vary from thegenotypes because of encironmantal influences.

· chromosomes often recombine

Anticipation is caused by amutation that increases in expressivity over subsequentgenerations.

Answer

· True

· False

Question 44

I have a genotype that shouldproduce a specific phenotype, but some of the individuals with thegenotype do not demonstrate any evidence of the phenotype. I wouldconsider this an example of

Answer

· allelic heterogeneity.

· locus heterogeneity.

· penetrance.

· expressitivity.

· sheer luck.

Question

Which of the following doesnot occur during the PCR reactions?

Answer

· Changes in the reaction temperature by athermocycler

· Denaturation at high temperatures

· Synthesis of oligonucleotide primers

· Extension of primers by DNA polymerase

· Annealing of oligonucleotide primers

Question

DNA markers, or variantnon-coding regions of DNA, are DNA polymorphisms that are usefulfor genetic mapping.

Answer

· True

· False

A mosaic is an organismwith

Answer

· multiple genotypes within one organism

· multiple alleles within one genotype

· more than one color of fur

· transgenes added to the zygote beforedevelopement

· a wt phenotype but a mutated genotype

Question

Genotype causesphenotype.

Answer

· No, gentoype just influences phenotype.

· Yes, genotype is the DNA sequence that createsphenotype.

Question

A true genetic chimera can becreated by

Answer

· mutating a gene early on in the development of anorganism resulting in different alleles being present in theadult

· multiple fertilized eggs or zygotes fusing to formone embryo

· adding a transgene to the genome of an organismduring fetal development only

· adding cells of a different species to an adultorganism

· adding a transgene to the genome of an animal atany stage in development

Question

The ABO blood group can bestbe explained by the concept of _______.

Answer

· dominant traits

· recessive traits

· allelic heterogeneity

· locus heterogeneity

· vampirism

If a loss of functionmutation creates a dominant phenotype, it may be becauseof

Answer

· haploinsufficiency

· penetrance

· expressivity

· allelic heterogeneity

· locus heterogeneity

Please select the best matchfor each.

Answer

· PCR: Technique used to generatecopies of a DNA fragment

· Southern blot : Screeningprocedure used to assay DNA fragments

· RFLPs : DNA fragments generatedby restriction enzymes that vary in length betweenindividuals

· Northern blot : Screeningprocedure used to assay mRNA fragments

· Electrophoresis Movement ofmacromolecules in an electrical field

Answer

A.

Screening procedure used toassay DNA fragments

B.

Movement ofmacromolecules in an electrical field

C.

Screening procedure used toassay mRNA fragments

D.

DNA fragments generated byrestriction enzymes that vary in length betweenindividuals

E.

Technique used to generatecopies of a DNA fragment

A gene mutates, and theprotein produced has a novel way of interacting with the cell, andcreates a new phenotype because of this new functionality. This iscalled

Answer

· pleitropy

· locus heterogeneity

· allelic heterogeneity

· dominant negative mutation

· gain of function dominant mutation

Question 62

Mutations in the somaticchromosomes may be inherited by the next generation.

Answer

· True

· False


A degenerate PCR primer withmany variant sequences must be used to make multiple copies of agene

Answer

· if only the protein sequence of the gene productis known to construct the primers

· if the DNA you are using is cDNA to constructthe primers

· if the DNA you are using is genomic DNA to becopied

· if the DNA you are trying to copy iscDNA

· if the vector is prokaryotic and the transformedcell is eukarytotic

Question

Please select the best matchfor each term.

Answer

· Restriction enzyme


· PCR C

· Plasmid

· YAC A

· Dideoxynucleotide

Answer

A.

Endonuclease isolated frombacteria

B.

Eukaryotic cloningvector

C.

Method for amplification ofDNA sequences

D.

Small circular fragment ofDNA

E.

Molecule used in DNAsequencing

Question

A couple goes on MauryPovitch, and the results are in: you are not the father. But noother man impregnated the female (granted, unlikely for a MauryPovitch guest, but work with me here) and he must be the father.DNA analysis claims otherwise, though the child definitely wasmom's (poor thing). What may be going on here?

Answer

· the child is parthenogenic because the motheractually impregnated herself like a shark, and the child's DNA isall mom's

· the child had a mutation that changed the genethat is used to trace paternity

· the child is a mosaic because he is actually a setof twins fused early during fetal development, and therefore camefrom 2 eggs and 2 sperm

· the dad may have germ-line mosaicism, meaning thatthe genotype of his sperm is different from his somaticgenotype

· mitochondrial DNA only comes from mom, so there isno way to tell whobthe baby's father is




1. Characters that show a continuous range of variation, such as height and eye color, usually are controlled:

a. by a single gene with two alleles that are codominant.
b. by many genes with an additive effect.
c. by epistatic interactions between two genes.
d. mainly by the environment, with only a small genetic component.

2. In humans, red-green colorblindness is inherited as a sex-linked recessive trait. In order for a woman to be red-green colorblind, which of the following statements must be true.

a. Her mother must be red-green colorblind.
b. All of her brothers must be red-green colorblind.
c. Her father must be red-green colorblind.
d. All of the above statements must be true if a woman is red-green colorblind.

3. The x-ray crystallography data collected by Rosalind Franklin suggested to Watson and Crick that the:

a. structure of DNA is a double helix.
b. two strands of the DNA molecule are joined by hydrogen bonds between the bases.
c. four bases within DNA pair in a specific way.
d. two strands of the DNA molecule are joined by covalent bonds between the bases.

4. In the genetic code, _________ one amino acid.

a. one nucleotide specifies
b. two nucleotides specify
c. three nucleotides specify
d. four nucleotides specify

5. During Meiosis I, a homologous pair of chromosomes may not separate, resulting in daughter cells that have extra chromosomes or are missing chromosomes. This can lead to genetic disorders, including Down Syndrome. This phenomenon is called:

a. independent assortment.
b. nondisjunction.
c. segregation.
d. crossing over.

6. You are a human geneticist studying the incidence of retinitis pigmentosa in the residents of Tristan de Cunha, a group of small islands in the middle of the southern Atlantic Ocean. The allele for retinitis pigmentosa, which causes a form of blindness, is inherited as an autosomal recessive. You have determined that the frequency of this allele (r) in the population is 0.4 (40%). Using the principles of the Hardy-Weinberg rule, you would estimate the frequency of individuals who are heterozygous for this allele (Rr) in the population to be:

a. 0.16 (16%)
b. 0.24 (24%)
c. 0.36 (36%)
d. 0.48 (48%)

7. Natural selection acts at the level of the:

a. phenotype.
b. gene.
c. population.
d. nucleotide.

8. You are working with pea plants, trying to recreate the experiments that Mendel performed. You are doing a dihybrid cross with a plant that is heterozygous for both seed shape and seed color, with the genotype RrYy. Which allelic combinations would you expect to find in the gametes produced by this plant?

a. This plant would produce only RY and ry gametes.
b. This plant would produce only RrYy gametes.
c. This plant would produce RY, Ry, rY, and ry gametes.
d. You cannot determine which gametes this plant can produce without knowing the genotypes of its parents.

9. Biochemist Erwin Chargaff found that in DNA there is a special relationship between the four bases that we now call Chargaff's rule. His observation was that, in an organism's genome the:

a. percentage of A nucleotides = the percentage of T nucleotides, and the percentage of C nucleotides = the percentage of G nucleotides.
b. four bases all occur in an equal frequency (25%) within each organism.
c. percentage of A nucleotides = the percentage of G nucleotides, and the percentage of C nucleotides = the percentage of T nucleotides.
d. genetic material is composed of proteins, not DNA.

10. During DNA replication:

a. each strand of the double helix acts as a template for the synthesis of a new strand.
b. the enzyme DNA polymerase adds nucleotides to the strand being synthesized.
c. the bases A,C,G and T are required.
d. All of the above are true of DNA replication.

11. During translation, amino acids are joined by peptide bonds to make polypeptides. The formation of these peptide bonds is catalyzed by:

a. DNA.
b. mRNA.
c. tRNA.
d. rRNA.

12. If an allele (R) at a gene with two alleles shows complete dominance, individuals with the genotypes ______ will have the same phenotype.

a. RR and rr.
b. RR and Rr
c. Rr and rr
d. Each of the three possible genotypes will have a different phenotype.