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Lecture 16

BIOL 207 (10/21/13) Lecture 16, 17, & 18

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University of Alberta
Biology (Biological Sciences)
Mike Harrington

BIOL 207 (October 21, 2013) Lecture 16: Human Pedigree Analysis – Part 2 (con’t) | Lecture 17: Population Genetics | Lecture 18: Interactions Between Genes – Part 1  Pedigree charts not good for new mutation o Example: Achondroplasia is usually a brand new mutation (less likely to be inherited than to occur due to spontaneous mutation)  Inherited = 20%  New paternal mutation = 80%  The older the dad is, the more likely the child is likely to develop Achondroplasia  Mutation increases cell division in germline cells… result over time? Most sperm will end up carrying the mutation Complications in Pedigree Analysis  New mutations o Pedigree charts are best used for inherited mutations  Possible Errors: o Lack of paternity/maternity  Sperm bank  Adultery  Adoption o Testing errors o People don’t admit to having serious conditions (societal stigma)  Multifactorial diseases o MOST disease are not a result of a single mutated allele but rather, mutant alleles of SEVERAL genes and the effect of the environment. Start of Lecture 17: Population Genetics Frequencies of genotypes and phenotypes in a genetic cross  Codominance ratio for the F2 (3rd) generation  1:2:1 o What would the fourth generation look like?  It would be the same! Why? Because the frequency of the gametes and
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