Lec08_140122.docx

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School
University of Alberta
Department
Biology (Biological Sciences)
Course
BIOL299
Professor
Darren De Lorey
Semester
Winter

Description
BIOL207 B01 Lec08 2014-01-22 CHAPTER 4 (cont’d) A. Mutation Classification (cont’d) a. point mutation (substitute one base for another) b. insertion or deletion (indel) c. effect on gene function (Muller moprhs) i. amorph = null = no wt protein function ii. hypomorph = partial loss of wt function iii. hypermorph= more of the wt function than in wt iv. neomorph = a new function that is different from wt v. antimorph = a new function that works in opposition to wt d. loss-of-function (amorph, hypomorph) vs. gain-of-function (hypermorph, neomorph, antimorph) e. amorph, hypomorph tend to be recessive because wt alleles tend to be haplosufficient f. hypermorph, neomorph, antimorph tend to be dominant B. Mutant screening: Salvation of Doug http://bio.research.ucsc.edu/people/sullivan/savedoug.html a. learn about almost any biological process by identifying mutants that disrupt that process
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