CELL201 Lecture Notes - Lecture 15: Myosin Head, Myosin, Nebulin

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Cell movement ii: each muscle fibre contains numerous myofibrils, myofibril is divided along its length into repeating units called sarcomeres, sarcomere contains bundles of thin filaments (actin, troponin, tropomyosin) and thick filaments (containing myosin) M line: m line contains myomesin (links myosin filaments together, distance between consecutive z lines define a sarcomere. Thick filaments: hundreds of myosin molecules oriented in opposite directions, myosin heads protrude out and make contact with the thin filaments. Sliding filament model: thin filament sliding past thick filaments without change in length, myosin is an atpase. Regulation of ca2+ levels: controlled by nerve impulses from motor neurons, ca levels increase, muscles contract, ca levels decrease muscles relax, the sr has calcium atpases to pump calcium into the sr. Muscle fatigue: neutral fatigue- strength of signal (depletion of vesicle stores) and maintenance of signal (receptor desensitization, metabolic fatigue: atp levels, calcium dynamics, metabolite build-up (pi)

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