CELL201 Lecture Notes - Lecture 10: Connexin, Sodium Channel, Cell Membrane

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Ultimately to change the behavior of the cell you have to alter the functioning or some kind of machinery inside. A lot of the times it involves the change of the transcriptional program in the nucleus. It is a long distance to the nucleus from the plasma membrane. Membrane potential is a di erence in charge. Using atp, na-k pumps, pump 3 na out and 2 k in. Sodium channels are gates at both sides. When threshold is exceeded, positives start coming into the cell. Now more positive on the inside of the cell. Causes the membrane potential to drop again and become more negative. No action potential because all the na is inside all the ka on the outside. Position needs to be ipped through the na-k pump for action potential to re again. Some stimulus will cause it to become less negative on the inside. + on the inside - on the outside.

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