CELL201 Lecture 16: Lecture 16: Cell Adhesion and ECM
10 Apr 2018
School
Department
Course
Professor
Document Summary
Cell adhesion, junctions and extracellular structures: all the cells in a developing organism are in constant communication with each other, cells are in physical contact and are sharing information. Types of tissues: epithelium: sheets of cells, tightly connected, polarised. Apical region: involved in the job that needs to be done. Basolateral region: basal lamina, polarised cell because one side only secretes in some cells. In the gut, enzymes only need to be released in the side facing the gut: connective: loosely organised, bone, not stuck to each other, embedded in matrix, nervous: nerves and neurones, muscle tissue. Cell- cell adhesion: use adhesion receptors to attach to each other, class of cell- cell adhesions. Selectins: like cadherins, ca dependent, interact with glycoproteins, a lot of important immune markers have a cd77 or cd92 and they bind to specific selections. Integrins: usually dimers of transmembrane proteins, they can be turned on and off: homophilic interactions: identical receptors on surface interact.
