CELL201 Lecture Notes - Lecture 11: Receptor Tyrosine Kinase, Signal Transduction, Arrestin
16 Mar 2018
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Document Summary
Problem with developing things that target receptors or enzymes inside the cell: cells are systems that respond very readily to alterations in the signal transduction pathway. Its only the changes in their relative concentrations that the cells respond to. There might always be a certain level of hormone/chemical/etc. Only when the concentration changes a great deal, you will get an e ect on the cell. Addiction is the inability to respond to the same thing with the same amount. Cells don"t make that receptor anymore- so express less. Internalize the raptors they have already got. None of these happen in isolation , there is crosstalk. If we turn on pka its starts turning on other things too. Its only target is not gpcr it targets other signaling cascades. The vesicles hide from extra cellular ligands. There are fewer receptors that can transduce that signal to the inside. Other kinases other than pka can act.
