GENET301 Lecture Notes - Lecture 3: Knockout Mouse, Cytosol, Ubiquitin Ligase
23 Sep 2016
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Even been suggested that mitos may have a mechanism for sorting damaged material to one end of a mito. Some evidence suggests that the system of qc is defective in parkinson"s disease (pd) Illegal drug use in the "70s - found buildup of a substance in the substantia nigra. This substance reduced activity of complex i in etc. Most (90%) of pd cases are sporadic with unknown cause. But, several genes known to be involved in hereditary forms of the disease. Mutations in these genes lead to early onset parkinson"s (young adults and children) ex. Pink1 gene - pten-induced putative kinase 1 (pten - phosphatase and tensin homologue) ex. Roles of pink1 and parkin in mt qc not entirely understood, but appear to be required for the. It is known that pink1 contains a mt targeting signal that brings it to mitos. It is then partially imported through the mim.
