IMIN200 Lecture Notes - Il17A, Macrophage, Interleukin 4
SchoolUniversity of Alberta
DepartmentImmunology and Infection
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1) What are cytokines? And what are the three different types of action if produces? Are they all soluble?
2) Cytokines mediate numerous biological function individually or in combination with other cells: Explain
Pleiotropic and Redundancy
3) Explain Synergy and antagonism.
4) What is cascade induction?
5) All in all, what do cytokines general role?
6) What are the three major cytokines producers? 4 things cytokines are essential for?
7) IL-12, IFNγ produces what kind of TH response?
8) IL-4, IL-5 produce what kind of TH response
9) IL-17, IL-23 produce what kind of TH response
10) If cytokines can activate all immune cell populations, give 4 reason why adaptive immune response
continue to be highly specific to particular antigens?
11) How many families of cytokines are there? How are they distinguished from each other? Their name?
12) What is the job of cytokines that belong to the interleukin 1 (IL-1) family? What are some examples of
13) Interleukin 1 receptor family: what kind of receptor are these?
14) Why do you want to regulate the signaling caused by IL-1 binding? What are the two ways that we
regulate this signal that?
15) Hematopooietin (class I cytokines): where they originate? How are they different and similar to each
other? What are its effect?
16) Hematopooietin receptor family: why do they have different sub-families? Name one of the receptor?
How does the affinity of this receptor change?
17) Interferon ( class II cytokines): Type 1 Interferon ( and ): what type of effect does it have and how does α β
it do this ? Secreted by what cells?
18) Type II interferon (AKA interferon ): produced by what cells and their main role is? The most important γ
type II is? What cells produce this cytokines? Do we have any other types of interferon?
19) Interferon receptors: what type are they? Does it just bind one cytokine?
20) Tumor Necrosis factors (TNF) cytokines family facts: give example of both the soluble and the 5
important physiological membrane bound members? Are they heterodimers? Main function of these
cytokines (3 functions)?
21) Tumor Necrosis factors (TNF) receptor family: what type of receptors are they? Are they just death
receptors? How can they become soluble?
22) How does Fas induced death? Why is this important function?
23) Interleukin 17 cytokines family: give example of these? Expressed by what cells? What are they
important for? What is IL-17E function?
24) Interleukin 17 receptor family: what cells have these? Diversity?
25) Chemokine family: to what class of compound do they belong to? What is their main function?
26) How does chemokine family cause migration?
27) What dictates Chemokine structure?
28) Explain the chemokine receptor (types, unique about them, etc)
29) Where does cytokines antagonist comes from? Give example of some
30) What do we usually see in a diseased individual? What is Cytokines therapy?
ANSWERS: lecture 1
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