IMIN200 Lecture Notes - Lecture 3: Sphingosine, Chemokine Receptor, Autoimmune Regulator

• School: University of Alberta
• Department: Immunology and Infection
• Course: IMIN200
• Professor: James Stafford

Document Summary

1) form in bome marrow(cid:224)migrate to the thymus through the blood(cid:224) dp(cid:224)positive and negative selection occurs to leave only sp (cd4 or cd8)(cid:224)final screening removes the auto reactive(cid:224)release into blood: dn is the stage in which the tcr beta (b) gene recombination occurs at this moment it will become t cell but it leads to two different types of cells either or t cell. Chain rearrangement and stimulates cd4 and cd8 expression (dp cell real now) and stops addition b rearrangement (allelic exclusion) and stimulates proliferation: progeny cells will pair the same with different chains=increase. This peptide and mhc combination will select a tcr will a similar v regional diversity: only peptides that presented in the context of mhc (self) will produce a specific response by the t cells otherwise no response occurs, instructive model(cid:224) specificity of the pre tcr determines which co receptor to express ( i. e. tcr bind mhc i(cid:224) cd8 are expressed).