1) What are the cells that are the mediators btw innate and adaptive? Why?
2) Are their any other cells that are involved? Explain how they help?
3) Different btw the Th1 and TH2 response?
4) Explain how there is constant interplay between the innate vs. adept?
5) IL12 from DC produces what T cell? IL10 produced what response? IL6 and 23
6) What determines what types of TH cell subset?
7) Why do naïve CD4 T cell in the presence of IL12 produced by DC and IFNγ by
NK make TH1 response?
8) Why do naïve CD4 T cell in the presence of IL4 produced by NK and IL10 by
DC make TH2 response?
9) Explain why Tbet and Gata 3 wer found to have that specific function?
10)Explain the whole process of TH1 cell production start at binding?
11) Explain the whole process of TH2 cell production start at binding?
12) If Th1 cell is formed can th2 cells be also formed?
13) Name the other 3 master regulating genes that we have?
14) What is the name of the key cytokines for the differentiation of both the Th17
and the Treq cells.
15)Which cytokine is the switch that allows ROR γ t to dominate over Treq.
16) How does the two types of leprosy show the consequences of an inappropriate
immune response generation?
17) Explain the process of how Effector cells die when they clear infection?
18) What do we see in a patient with the defective FasFasL if you inject Antifas
19) How do the roles of Cd28 and CTLA4 differ?
20)FCgammaRIIB1 signal in last lecture ( midterm 2) important,
1) Dendritic cells are the key bridge (TLR on it). They bring antigens from the site
of infection and present them to naïve T cells in lymph nodes. This activates the T cells, allowing them to differentiate into particular pathogenspecific subsets of T
cells (TH1.2.17 or the Cytotoxic T cells).
2) NK cell activated by the IFNα and IFNβ will then secrete IFNγ that will
activates macrophages and dendritic cells ( thus move adaptive TH1 resp). We
also have NKT cells produce IL4 and drive the response towards TH2.
3) TH1▯cell mediated(macrophages, DC, NK and neutrophils or so on) And TH2 ▯
humeral (B cells) mediated).
4) We see a very similar type of things btw the two systems. The innate helps to
initiate and regulate adaptive immune responses (mostly using cytokines). There
are certain mechanisms that the adaptive system has actually copied from the
innate like opsonization, complement activations, and even some lymphocytes of
the adaptive immunity have the TLR (major role in innate) that are used as co
5) TH1 (usually bacteria▯extracellular)▯IL12. TH2▯IL10 (worms▯intracellular) TH
17▯IL16 and 23 (influence response)
6) The types of cytokines released by different cells they bind on its respective
receptor. Once they do they activate this master gene regulator which activates
specific genes for specific subset.
7) Tbet (master gene regulator) is activated leading to TH1 genes
8) Gata3 (master gene regulator is activated) leading to TH1 genes