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Lecture

Lecture_3_Summary.pdf

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School
University of Alberta
Department
Immunology and Infection
Course
IMIN200
Professor
All
Semester
Fall

Description
LECTURE #3 – TLR SIGNALING After studying lecture #3, you should be familiar with the following concepts. 1. PAMP- PRR Interactions. Pathogen Associated Molecular Patterns (PAMP) are microbial molecules that interact with host Pattern Recognition Receptors (PRR) to alert a host to microbial presence/invasion. Once active, host PRR initiate intracellular signaling cascades that drive rapid innate immune defenses. PAMP/PRR-based defenses are ancient and evolutionarily conserved. 2. Toll-Like Receptors (TLR). TLR are classical PRR that illuminate many key features of the signaling pathways that underpin innate immune responses. TLR have a modular architecture with three distinct domains. The N-terminal Leucine Rich Repeats (LRR) bind PAMPs. The transmembrane domain anchors TLR in the membrane and ensure that TLR have appropriate access to PAMPs. The C-terminal intracellular Toll Internal Repeat (TIR) engage intracellular adaptor molecules to initiate TLR signaling. There are numerous versions of TLR (e.g. approx. ten in the human genome) with varying specificities and distinct signaling outcomes. This ensures that the correc
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