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Immunology and Infection
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LECTURE #1 – INTRODUCTION After studying lecture #1, you should be familiar with the following concepts. 1. Immunity. Immunity is loosely defined as resistance to infectious disease and the immune system is defined as the cells, tissues and molecules that mediate resistance to infection. Historically, the discovery of immunity is rooted in the discovery of immunological memory. It was observed that exposure to infectious agents provided a form of protection against subsequent infections, as if the immune system somehow “remembered” the appropriate defenses against a specific microbe. The discovery of immunological memory spurned the development of vaccination strategies that have virtually eliminated numerous deadly diseases such as smallpox, polio, etc. 2. Forms of Immunity. Immune responses are roughly divided into three categories – protective barriers; innate immunity; and adaptive immunity. The bulk of this section is devoted to the study of innate and adaptive immunity. 3. Barriers. Skin and
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