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Lecture

CHAPTER_5___Cellular_immunity.pdf

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Department
Immunology and Infection
Course
IMIN200
Professor
All Professors
Semester
Fall

Description
CHAPTER 5 – CELL-MEDIATED IMMUNE RESPONSES (FROM THE TEXT) Summary. 1. T lymphocytes are the cells of cell-mediated immunity, the arm of the adaptive immune system that combats intracellular microbes, which may be microbes that are ingested by phagocytes and live within these cells or microbes that infect non-phagocytic cells. 2. The response of T lymphocytes consists of sequential phases: recognition of cell- associated microbes by naïve T cells, expansion of the antigen-specific clones by proliferation, and differentiation of some of the progeny into effector cells and memory cells. 3. T cells use their antigen receptors to recognize peptide antigens displayed by MHC molecules on antigen-presenting cells (which account for the specificity of the ensuing response) and polymorphic residues of the MHC molecules (accounting for the MHC restriction of T cell responses). 4. Antigen recognition by the TCR triggers signals that are delivered to the interi
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