IMIN405 Lecture Notes - Lecture 3: Signal Transduction, Post-Translational Modification, Ptpn6

• School: University of Alberta
• Department: Immunology and Infection
• Course: IMIN405
• Professor: James Stafford

Document Summary

Do not undergo many modifications (non-tcr, non-bcr receptors) The specificity of the response depends on the cell itself. Receptors (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) (cid:12254) Plasma membrane proteins expressed on the cell surface. Have an agonist - something that the receptor binds to. Once bound/activated, the receptor associates with intracellular effectors - something happens that changes the receptor into its on state. Signal transduction - secondary and tertiary (etc. ) effectors amplify the signal -- signal cascade. The cell can integrate this information into a response. Selected cascades of signalling bias the system towards a specific response. Modification of phospholipids - makes them more attractive to effectors - recruitment to the membrane. The tyrosine residue is embedded within a domain. Sh2 domains - look for phosphorylation at tyrosines within specific motifs.