MMI445 Lecture Notes - Lecture 10: Neisseria Meningitidis, Meningococcal Disease, Serotype

• School: University of Alberta
• Department: Medical Microbiology and Immunology
• Course: MMI445
• Professor: Judy Gnarpe

Document Summary

Virulence factors: polyssacharide capsule, antigentically classed into 12 serogroups. A, b, c, y, w-135, x: invasive disease. Virulence factors: los endotoxin, highly toxic, imbriae or pili- attach. Exists as normal lora in 5-15% of adults: can start out as fever, headache, stif neck. Disease: meningococcal meningitis, meningococcemia, can present with purpric rash. Transmission: direct contact with respiratory droplets, patients or asymptomatic carriers, humans only host. Culture of csf or blood- chocolate agar: biochemical reactions. Pcr: target ctra gene of m. meningitidis- capsular polysaccharide transport protein. qpcr: serogrouping. Meningococcal disease, invasive: conirmed: clinical evidence of invasive disease with laboratory conirmation of infection: isolate the organism from sterile site: blood csf, pleural, synovial or pericardial luid. Probable: clinical evidence of invasive disease, with detection of: meningitidis antigen in csf, in absence of isolation of a sterile site. Risk factors: serogroups, nasopharyngeal carriage, warning immunity, environmental factors, demographic factors, socioeconomic factors, concurrent infections. Epidemiology: sterile swap is passed gently into the nasopharynx.