MICRB316 Lecture Notes - Lecture 20: Riboswitch, Ribozyme, Stem-Loop
4 Apr 2016
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Document Summary
Ribozyme regulation srna regulation, protein regulation and ribozyme regulation! Organisms proit by only synthesizing proteins that are in demand. Instead of using repressor or activators, or even anti-sense rnas, there is another mechanism of regulation! Rna molecule with enzymatic activity: ribozyme, a switch! Ribozymes have been previously discovered to catalyze fundamental reactions required for rna processing, esp. in euk mrna undergoing mrna intron splicing. It is also known that some mrnas with specialized domains can bind metabolites and control gene expression through either tl initiation or termination without the need for protein factors. Ribozyme: need to get rid of intron between exon i and exon ii- catalytic reaction chops the rna in half makes a closed loop and rejoins the exons with invisible joint- perfect protein when translated. Ribozyme catalytic core- binds join and cuts out intro leaving the exons. When mrna bind speciic compound mrna conformation changes tl or no tl.
