MMI133 Lecture Notes - Lecture 12: Complement Membrane Attack Complex, Anaphylaxis, Allergic Rhinitis
11 Oct 2016
School
Department
Course
Professor
Document Summary
Released to bloodstream inactivated to defend against pathogens. Complement system: group of ~20 serum proteins made by liver. Antibody-antigen = immune complex complement can be activated mac (insert into bacterial cell membrane and blows it apart) Important for blood-borne pathogens in those with poor immune system septicemia: classical: always activated by antibody-antigen complex, alternative: broken down cells, lipopolysaccharide etc activates this (cid:894)(cid:862)other thi(cid:374)gs(cid:863)(cid:895, lectin: do(cid:374)"t worry a(cid:271)out this; triggered by mannose. Split products/by-products (exp c3a and c5a) = very pro-inflammatory. C3a + c5a inflammation via release of histamine. Does not matter how complement system is activated; end result = mac formation. Note: do not have to know sequence of enzymes activated. Mac: forms a pore structure which allows fluid (water) to move freely across membrane and osmotically lyse the cell. Important c products to know the functions of (know this) Produced in the liver during infections: levels indicate infection.
