MMI133 Lecture Notes - Lecture 23: Epstein–Barr Virus, Infectious Mononucleosis, Subclinical Infection

• School: University of Alberta
• Department: Medical Microbiology and Immunology
• Course: MMI133
• Professor: Judy Gnarpe

Document Summary

Normal flora - alpha-streptococci (like acidic ph on mucous membranes) Spreads to sinuses, lower respiratory tract and middle ear. Optimal at 33 degrees celsius (upper respiratory tract conditions) Ebv: epstein barr virus is a major cause. Young people have subclinical infection (shows no symptoms) More severe at an older school age. Systematic effects on cardiovascular and lymphatic system. Produces heterophile antibodies (causes agglutination in other mammal"s rbc) Ampicillin rash - complication if you are given beta-lactam antibiotics (this is not just a rash) Streptococcus pyogenes - beta-hemolytic streptococci (strep group a) Strep throat cannot be visually differentiated from other infections, requires lab tests. Rapid tests are specific but not sensitive (+ results are meaningful, - results are inconclusive) Must test streptococcus pyogenes with antibiotics to prevent sequelae. S. pyogenes produce erythrogenic toxin, you can get scarlet fever. First strep throat can produce superantigen toxin , which leads to scarlet fever.