MMI133 Lecture Notes - Lecture 30: Gram Staining, Nociceptor, Rabies Virus
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16 Jul 2018
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Bone and spinal cord are protected by bone. Ganglia - small bodies containing sensory nerve cells located near the spinal column. Motor nerve cells - located in the spinal column. Meninges - 3 membranes covering the surface of the brain and the spinal cord. Meningitis - inflammation or infection of the meninges. Fills the 4 ventricles of the brain. Low levels of antibodies and complement (normally) Sterile (100-160 ml), normally very few wbc/ml (0-5) Restricts passage of cells and molecules between blood and csf. Some bacteria colonize into this layer and break it. Prevents some antibiotics from crossing into the csf, only few can cross the barrier (e. g. ceftriaxone, penicillin also does not cross into an intact brain) Main source of cns infections, but organisms must pass through the blood-brain barrier (some viruses can pass unharmed, e. g. polio) Some viruses travel through the axon cytoplasm and along the nerve bundles (e. g. rabies,
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