MMI436 Lecture Notes - Lecture 3: Omega-3 Fatty Acid, Reactive Oxygen Species, Prostaglandin H2
4 Apr 2016
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Document Summary
Major routes of mediator release from inflammatory cells: not just one process. 1. lipid mediator release: enzyme action on membrane bound lipids: reactive oxygen species production, degranulation and exocytosis, extracellular traps. Lipid mediators: many pro-inflammatory lipid mediators derive frm arachidonic acid: cleave product from phospholipids in cell membranes being hydrolyzed by phospholipase a2 phospholipase a2: blocked by glucocorticoids. Arachidonic acid: can only be synthesized from dietary sources- syntheisized from linoleic acid: long precursor molecule for eicosanoids; large collection of lipid mediators including prostanoids (prostaglandings), thromboxanes, and prostacyclin prostaglandins: potent lipid mediators of immune system. Biosynthesis of eicosanoids: arachidonic acid > lipoxygenase pathway + _____ cyclooxygenases: arachidonic acid to prostaglandings: starts with cyclooxyrgenase aspirin, ibuprofen, naproxen, paracetamol: inhibit cyclooxygenase: aspirin: non reversible inhibitor number in prostaglandin: bond. Eps: bind to receptors for peg2 occurs in mast cells and macrophates: vasodilation, hyperalgesia, fever, diuresis, immunomodulation. Pgh2: additional pathways where in the endothelium you can induce production of.
