MMI445 Lecture Notes - Lecture 3: Microorganism, Antibiotic Sensitivity, Aureus

• School: University of Alberta
• Department: Medical Microbiology and Immunology
• Course: MMI445
• Professor: Judy Gnarpe

Document Summary

Chemotherapy- the use of drugs to treat a disease. Selective toxicity- a drug that kills harmful microbes without damaging the host. Penicillin: g+ (g- pdgn thick layer doesn"t allow the penicillin to access the penicillin binding proteins) No antibiotic is effective against all microbes: hepatitis c can be cured with antivirals. Dna replication- bacteria have different polymerases and gyrases. Drugs: rifampin targets polymerase and ciprofloxacin targets gyrase. Inhibit cell wall synthesis: penicillin, cephalosporin, bacitracin, vancomycin. Colistin* last line of antimicrobials- now some resistant strains have been found- mcri. Penicillin penicilloic acid (doesn"t bind pbps as well) Susceptible: implies that an infection due to the strain may be appropriately treated with the dosage of antimicrobial agent recommended for that type of infecting species unless otherwise contraindicated. Intermediate: implies clinical efficacy in body sites where the drugs are physiologically concentrated or when a higher than normal dosage can be used ex: urinary tract infection vs. meningitis.