NEURO410 Lecture Notes - Lecture 16: Pars Compacta, Basal Ganglia, Lrrk2
12 Oct 2016
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Document Summary
Lecture 5: pd: basic science (march 8 / 16) Primarily caused by loss of da production in the areas of the brain that are responsible for voluntary movement: pd = considered movement disorder. Over 1 million us adults and 130,000 canadians are affected with pd number expected to double by 2030. Results in lost productivity and medical costs of ~ billion annually. Pd is primarily a disease in the elderly and although perhaps 4-5% of cases occur before age. 50, cases of parkinsonism in children are extremely rare. Men get pd at a much higher rate estimated ratio of men to women with pd about 2-1. Incidence of new diagnoses cases of pd is 19. 1/100,000 for men, 9. 9/100,000 for women annually in 2013. Pd caused by the gradual loss of da producing neurons in the substantia nigra pars compacta and striatum by direct cell death and/or from the resultant inflammation from sick and/or dying neurons.
