NURS113 Lecture Notes - Lecture 2: Ionizing Radiation, Dysplasia, Histamine
11 Jan 2016
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Lack of oxygen to cell/tissue which leads to accumulation of metabolic wastes. Caused by ischemia interruption of blood flow to area. The most common cause of cell injury and injures cells faster than hypoxia alone. Reduced o2 delivery > little atp produced > increased lactic acid . > decreased ph > structures critically damaged > cell dies. Ischemia-reperfusion injury: most cellular damage when blood restored, o2 restored > o2 free radicals formed and overload of ca2+ > disorganized burst of high energy electrons. **cell does not die from initial injury, it dies from the reperfusion: ex: babies should not receive high amounts of oxygen because their retinal cells can die and the baby can become blind. Monday, january 11, y: poverty, chronic alcoholism, acute and/or chronic illness. Excessive intake: bmi > 27 kg/m3 = health risk, bmi > 30 kg/m3 = obesity. Bacteria and viruses may injure cells in a variety of ways.
