NURS215 Lecture Notes - Lecture 3: Tachycardia, Perfusion, Acetylcysteine
19 Oct 2016
School
Department
Course
Professor
Document Summary
Pharmacodynamics is a branch of pharmacology concerned with the mechanisms of drug action and the relationships between drug concentration and responses in the body. Activation of a receptor outside the cell, stimulates and intracellular response. Sympathetic receptors are found almost anywhere in the body. Can cause many effects but also many side effects. Ex. epinephrine binds to the outside of the cell, causing a response inside the cell. When the drug binds to the receptor it either ions or closes ion channels, depending on design. Ex. lidocaine : inhibits depolarization = no pain transduction. Important for treating arrhythmia and local anesthetics: nuclear receptors. Most bind to cytoplasm (inside the cell), change cell history via dna. Enter the cell nucleus to change the function. Drugs that stimulate enzymes that are intracellular (within the cell: enzymes : transmembrane. Insulin binds to a receptor outside the cell membrane and the receptor activates an enzymes (tyrosine kinase)
