NURS215 Lecture Notes - Lecture 11: Antiplatelet Drug, Clopidogrel, Vasospasm

• School: University of Alberta
• Department: Nursing
• Course: NURS215
• Professor: Helena Schaefer

Document Summary

Dissolves in gi into aspartic acid, phenylalanine, methanol => hepatic metabolism. Clotti(cid:374)g : clot formation increases plaque size, clots form in angioplasty patients. 3 steps in the process of blood clotting (hemostasis): vascular spasm, platelet plug formation, blood coagulation (clotting) (cid:858)coagulatio(cid:374) cas(cid:272)ade(cid:859) i(cid:374)(cid:448)ol(cid:448)es large (cid:374)u(cid:373)(cid:271)er of e(cid:374)zy(cid:373)es a(cid:374)d (cid:272)lotti(cid:374)g fa(cid:272)tors (cid:894)esp. Vitamin k - required for synthesis of 4 clotting factors by hepatocytes (factors ii (prothrombin), Asa (blocks tromboxane a2 in degranulation; also cox 1 inhibition = decreased platelet aggregation) Asa otc, po, fast acting when chewed, effective mi 1st tx. Used in ptca to prevent cva/mi during procedure. ), vs, urine, lab work!, catheter sites, menstrual bleeding. Essential to blood coagulation (part of coagulation cascade: converts fibrinogen to fibrin, activates factor xiii, enhances platelet aggregation, facilitates its own synthesis. Inhibition of thrombin (= no fibrin!) i. e. heparin; low-molecular-weight heparin (i. e. Inhibition of thrombin (= no fibrin!) i. e. heparin; low-molecular-weight heparin (i. e. enoxaparin)