NURS290 Lecture Notes - Lecture 6: Golgi Apparatus, Protein Precursor, Axoplasmic Transport
5 Oct 2017
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Document Summary
Excessive neurotransmission of dopamine is associated with schizophrenia, a clinical condition marked by seriously disordered thought. Antipsychotics, also called neuroleptics, are a class of compounds with a high affinity for several subtypes of dopamine receptors. The chemical structure of the various antipsychotics allows them to bind to dopamine receptors without triggering the postsynaptic response that the binding of dopamine normally would. There are approximately thirty antipsychotic drugs presently available in north. These drugs illustrate a high affinity for the. D2 family of dopamine receptors and it is at these sites that they are thought to exert their therapeutic action. Some neuroleptics interfere with the release of da at the presynaptic terminal, while others block postsynaptic dopamine receptors so that postsynaptic cells cannot recognize dopamine. The inhibition of dopamine transmission in other pathways, however, can result in a wide range of highly undesirable side effects.
