NU FS356 Lecture Notes - Lecture 17: Nitric Oxide, Aldosterone, Vasopressin
13 Apr 2017
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Document Summary
Aging is a complex, multifactorial process, it is inevitable, irreversible. Physiological changes associated with aging does not start at a specific age. Increased self-destruction such as increase normal and controlled cell death-->apoptosis (notice that these physiological changes are based on genetic, lifestyle and environment) *characteristics: decreasing the ability to respond stress,(if over the limit of stress, result in death) and environmental stimuli, for example it decrease the ability to adapt homeostasis. Why we age: evolutionary, gene regulation, cell senescence, free radical, systemic-based such as neuroendocrine and immune. It is a natural selection only acts on genetic weaknesses prior to sexual maturity, there is no selection against aging. Genetic weakness such as diseases that are manifested after sexual maturity will stay in population. Mutation accumulation, which is a harmful, late-acting mutations may accumulate and ultimately lead to aging genetic, Aging process result from changes in gene expression (gene alteration) There are genes that when expressed, are associated with increased, longevity.
