PMCOL305 Lecture Notes - Lecture 1: Gamma-Hydroxybutyric Acid, Cleft Lip And Cleft Palate, Phenyl Group

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Alpha 1 subunits, alpha 5 in hippocampus. Only exert effects if gaba binds also. Depressant drugs benzos, barbiturates, gamma hydroxybutyrate (ghb) Gabaa receptors benzo binding site different from gaba binding site between alpha and gamma. Increase affinity of receptor for gaba, increase frequency of opening (allosteric effect) - hyperpolarized. Memory effects lose short term to long term memory transfer. (exploited in date rape). Pa(cid:396)ado(cid:454)i(cid:272)al sti(cid:373)ula(cid:374)t effe(cid:272)ts a(cid:374)(cid:454)iet(cid:455), i(cid:374)so(cid:373)(cid:374)ia, hallu(cid:272)i(cid:374)atio(cid:374)s. agg(cid:396)essio(cid:374), (cid:373)u(cid:396)de(cid:396) i(cid:374) (cid:272)h(cid:396)o(cid:374)i(cid:272) users. Hallmark of prenatal benzo exposure = cleft palate, other malformations. apoptosis in cns. Floppy infant syndrome rapid placental transfer of benzos high lipiphilicity of drugs. Half life of drugs increases, accumulates in fetus. Ofte(cid:374) used (cid:271)(cid:455) sti(cid:373)ula(cid:374)t a(cid:271)use(cid:396)s to take off (cid:862)edge(cid:863) esp opiods, cocaine. Reinforcing, despite apparent decrease in reward pathway. Gaba acting on gaba-a receptors produces some inhibitory tone. Inhibit gaba release of those neurons typically inhibiting da release. So less inhibition of da release so reward!

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