PEDS200 Lecture : Fatigue

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Lab tips y anaerobic, alactic system, use definitions y timing was off y have peak po and mean po. Interaction of factors y central and peripheral neural factors (firing or transmission rates of motor neurons), o2 supply, Substrate depletion (glycogen), metabolite accumulation/ ionic imbalance, phosphagen. Depletion (atp, pc), muscle damage, disease, ft/st distribution, environmental factors. Depletion of phosphagens y results from depletion of atp and pc stores y pc can deplete to about 15% of resting values y atp rarely depletes below 40% of rest y primary concern for sprinting and strength exercise. Accumulation of h+: y interferes with the activity of many metabolic enzymes & ca2+ binding at troponin as well as. May also stimulate nerve receptors which can elicit a pain response. Accumulaton of ca2+: y intereferes with relaxation during repeated high intensity muscle contractions, uncouples oxidative phosphorylation in mitochondria (swelling), activates muscle proteases that breakdown protein and damage mitochondria.

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